Serendipity
Curious
During the COVID pandemic, Maarten van der Elst, TU professor and surgeon at the Reinier de Graaf Gasthuis in Delft, saw first-hand how scarce intensive care beds had become in the Netherlands. Every evening, he and his wife, an anaesthesiologist at Rotterdam’s Erasmus Medical Center, would share their concerns after coming home from work. The hospitals were overcrowded and many patients needed oxygen therapy. There were several options: nasal cannulae, oxygen masks, or intubation. “All options required a lot of industrial oxygen, and we don’t have an infinite supply in the Netherlands,” Van der Elst explains. “Countries like India and England even saw their oxygen supplies dwindle to the point of running out during the pandemic.” Seeing what was happening in the world around them, van der Elst and his wife came up with an idea: What if they found a way to safely extract oxygen from the environment and administer it to patients? He posed this question to the students mechanical engineering who were doing their final bachelor project under his tutelage, exploring the possibilities of building an oxygen device that extracts oxygen from its own surroundings and can be administered non-invasively – while the patient is awake and breathing independently. The first step for the students was to find ways to extract oxygen from one’s surroundings. There are several ways, but a wide array of logistical problems and safety risks complicate matters. The only safe way was to use zeolite-mediated adsorption (a kind of mineral), which is a novel field for the students. Through Google, they accidentally stumble upon ‘zeolite expert’ and TU professor Thijs Vlugt, also affiliated with the Faculty of 3mE. Vlugt has extensive experience with zeolites in industrial projects, and although an oxygen device is not quite his bread and butter, his curiosity got the better of him and he invited the students for a meeting.
Fire alarm
Just before the meeting, a fire alarm triggers an evacuation and Vlugt and the students are forced to meet in the parking lot, where they make the initial sketches for an oxygen device using zeolite-mediated adsorption on the hood of a car. “Zeolite is a kind of crystalline substance with pores the size of a typical molecule,” Professor Vlugt explains. “Some molecules want to enter it, while others do not. There is a specific zeolite that contains lithium, which has a great preference for nitrogen but not for oxygen. If you expose this zeolite to air – which is 80% nitrogen and 20% oxygen – it will extract the nitrogen and oxygen remains.” Vlugt shared his findings with Van der Elst, and both see potential. This is where the project ends for the first group of students, who write a paper outlining the theory and instructions for a subsequent group of students to actually build the device.
Working prototype
Based on the instructions and designs, a second group of students set to work, sourcing most of the materials from a local DYI shop and ordering the zeolite from China, which was promptly delivered to their local tobacconists.Until they plugged it, the students had no idea whether the device would work. “Our task was to develop an oxygen machine that would perform 600% better than the current devices on the market and would run on mains power”, student Wouter Kastelijns explains. “We were moving into uncharted territory, but we were excited about experimenting.” The story has a happy ending, as the first working prototype has now been delivered. Van der Elst praises the students’ mentality: “The current generation of TU students is passionate about making an impact.” He would like to see work on the device continue, tweaking it for use in low-income countries. “Unlike in the Netherlands, where general anaesthesia is the norm, surgeries are often performed under local anaesthesia in low-income countries, and effective oxygen devices can really make a world of difference.” Applying for a patent is also an option, but Vlugt and Van der Elst prefer leaving that to the students. “From the perspective of TU Delft and the valorisation programme, there is still work to be done. We’d love it if a student were to come in and turn this into their graduation project.”
An unexpected discovery or special encounter. Scientific research is often a string of serendipitous coincidences This time: how a Google search led to a new, safer way to administer oxygen.
Text Marjolein van der Veldt
Prof. Maarten van der Elst (right) and zeolite expert Thijs Vlugt met by chance and were introduced by students researching how to build an oxygen device for their final bachelor’s project.
@Sam Rentmeester
The first working prototype of the oxygen device that extracts oxygen from its surroundings through zeolite-mediated adsorption.
@Sam Rentmeester